A call to action to address critical flaws and bias in laboratory animal experiments and preclinical research.

Summary: Have you ever wondered why so many medical breakthroughs in mice don't end up working in humans? A new study points to a big reason: poorly designed experiments. Researchers looked at animal studies from 2022 and found a shocking truth. Almost none of them—less than 3%—used proper, unbiased testing methods! Most skipped important steps like hiding which animal got the treatment (blinding) or mixing up the groups fairly (randomization). This bad science wastes money, harms animals, and slows down real cures. The authors say we urgently need to train special experts to design better lab tests so we can actually trust the results.