A multivalent 9-O-acetylated sialic acid-conjugated bacteriophage platform for antiviral and immunomodulatory therapy for human coronavirus OC43.

Summary: Coronaviruses are tricky because they change fast and can hide from our immune system. This makes them hard to treat. Scientists have created a new, tiny tool to fight them using harmless viruses called "phages." They attached special sugar molecules to these phages.

When a coronavirus tries to infect a cell, it gets tricked. It sticks to the sugar on the phage instead of the human cell! This stops the virus from making people sick. In tests with mice, this new tool not only stopped the virus but also helped calm down harmful swelling in the lungs. It helped the mice live longer and could be a great new way to fight viruses like the ones that cause COVID-19.