A Path to the Formation Mechanism of Propolis Nanoparticles, their Cytotoxicity on 3T3 Fibroblasts, Metastatic Murine B16F10 Cells, and their

Summary: Bees produce a waxy resin called propolis, long known for its natural healing properties. Scientists have now discovered that shrinking raw propolis into microscopic "nanoparticles" makes it even more effective. These tiny particles act like smart delivery capsules, holding onto powerful antioxidants called flavonoids. In laboratory tests, these nanoparticles showed a remarkable ability to be selective: they killed dangerous metastatic skin cancer cells at low doses, yet they actually helped healthy skin cells grow and thrive. Furthermore, tests on rabbits confirmed that a water-based solution of these particles does not irritate the skin. This suggests a promising path for natural, non-toxic cancer treatments.