Amino acid metabolism disorder and oxidative stress took part in EGCG alleviating Mn-caused ferroptosis via miR-9-5p/got1 axis.

Summary: Manganese is an essential metal, but too much of it acts as a pollutant that can severely damage the kidneys. In a study using common carp and kidney cells, researchers discovered that excess manganese causes "rusting" (oxidative stress) and disrupts amino acid metabolism, leading to a specific type of cell death called ferroptosis. However, there is good news: EGCG, a powerful antioxidant found in green tea, acts as a shield. By regulating a specific genetic switch (the miR-9-5p/got1 axis), this green tea compound helps balance the cells' metabolism and protects the kidneys from manganese toxicity.