An orally administered gene editing nanoparticle boosts chemo-immunotherapy in colorectal cancer.

Summary: Colon cancer is hard to treat because tumors can resist drugs and hide from the body's immune system. Scientists found that turning off a specific gene called TRAP1 helps fix this problem. To do this, they created a tiny, high-tech pill containing a gene-editing tool (CRISPR). When swallowed, this tiny pill passes through the gut and goes straight to the cancer. Once there, it turns off the TRAP1 gene, making the cancer cells weak against medicine and easy for the immune system to attack. In tests on mice, this new pill worked amazingly well to shrink tumors. This could be a powerful new way to fight colon cancer in the future.