Atypical manifestation of psoriasis in the elderly: possible expression of Mal de Meleda diagnosis review and case report.

Summary: Imagine having thick, red, and tight skin on your hands and feet that doctors mistake for severe psoriasis. This happened to an older patient who actually had a super rare genetic skin condition called Mal de Meleda (MDM). MDM usually starts in childhood and affects only 1 in 100,000 people. Because it looks so much like other skin problems, doctors often have a hard time figuring it out. The best way to know for sure is through a DNA test to find the exact genetic cause.