Cannabinoid exposure does not alter estradiol biosynthesis in human KGN granulosa cells.

Summary: With marijuana becoming legal in many places, more women are using it. But does it mess with female hormones? Scientists tested this by looking at special cells in the ovaries that make estrogen. They exposed these cells in a lab to THC and CBD (the active parts of cannabis) to see if hormone levels changed. The good news? The cannabis compounds did not change how much estrogen the cells made, nor did they alter the genes responsible for making it. While marijuana might affect hormones in other ways in the body, it doesn't seem to directly harm the ovary cells that produce estrogen.