Combination of YAP inhibition and photodynamic therapy induces dual DNA damage and activates STING pathway to enhance immunotherapy in uveal melanoma.

Summary: Eye cancer (uveal melanoma) is very aggressive and hard to treat. Standard immune therapies that work well for skin cancer do not work well for this eye cancer, helping only about 3 out of 100 patients. Scientists have created a new, promising treatment using tiny medical particles and laser light. This new method damages the cancer cells' DNA in two different ways. This damage sends a strong alarm signal to the body's immune system. When combined with standard immune drugs, this new light therapy helps cancer-fighting cells rush into the tumor to destroy it. This could be a great new way to help patients with eye cancer.