Comparison of icodextrin and glucose solutions for long dwell exchange in peritoneal dialysis: a meta-analysis of randomized controlled trials.

Summary: For patients with kidney failure, peritoneal dialysis uses a fluid in the abdomen to filter blood. Traditionally, sugar-based solutions (glucose) are used, but they have limitations. A new review of nine studies compares glucose to a starch-based alternative called icodextrin. The results are encouraging: icodextrin removes significantly more excess fluid and waste products from the body than glucose. While it caused skin rashes in some patients, it did not increase the risk of infection or death and was safe for remaining kidney function. Icodextrin appears to be a superior choice for patients needing better fluid management.