Development of amphotericin B inclusion complex formulation in dissolvable microarray patches for intravaginal delivery.

Summary: Treating yeast infections (vulvovaginal candidiasis) can be difficult because the standard antifungal drug, Amphotericin B, does not dissolve well in water, making it hard for the body to absorb. To solve this, researchers created a "smart patch" using dissolvable microneedles. They wrapped the drug in a special sugar molecule called beta-cyclodextrin to help it dissolve, then molded it into a patch using safe polymers. When tested on laboratory tissue samples, these patches were strong enough to be inserted easily, dissolved effectively, and delivered the medication deep into the tissue without causing irritation. This new patch offers a promising, pain-free way to treat infections more effectively than current methods.