Discovery of Nirmatrelvir (PF-07321332): A Potent, Orally Active Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Main Protease.

Summary: In early 2020, a new virus called COVID-19 spread across the world. Scientists worked fast to find a medicine to stop it. This paper tells the story of how they created a new drug named nirmatrelvir. It is a pill you can swallow that blocks the virus from copying itself inside the body. This was a huge step in fighting the pandemic!