Effectiveness of Brodalumab for Guselkumab-Resistant Pustulotic Arthro-Osteitis in Patients With Palmoplantar Pustulosis: Case Series.

Summary: Imagine having painful, swollen joints and skin blisters on your hands and feet. For some people, a medicine called Guselkumab clears up the skin but leaves the joints hurting. Doctors tried a different medicine, Brodalumab, on three patients who still had severe joint pain. The results were great! The new medicine eased their joint pain, healed their bones, and kept their skin clear. Some felt better in just two weeks, and they didn't need as many painkillers. This shows Brodalumab is a promising option for people whose joint pain won't go away with the first medicine.