Evaluation of (Z)-endoxifen as a potential therapy for glioblastoma multiforme through computational and experimental analyses.

Summary: Imagine using a smart computer brain to find new uses for old medicines. Scientists did just that! They used an Artificial Intelligence (AI) program to see if a breast cancer drug called endoxifen could fight other tough cancers. The AI pointed them to a deadly brain cancer called glioblastoma.

When the scientists tested the drug on brain cancer cells in a lab dish, it worked great—it stopped the cancer cells from growing and destroyed them. Next, they tested the drug in mice. While the drug was safe to use, it didn't shrink the brain tumors in the mice as much as they hoped. The scientists think this might be because of the specific type of mouse test they used, rather than the drug failing. Overall, this study shows how AI can help us find exciting new ways to fight brain cancer!