Exploring the fate of 6PPD in zebrafish (Danio rerio): Understanding toxicokinetics, biotransformation mechanisms, and metabolomic profiling at environmentally relevant levels.

Summary: Scientists are investigating a chemical called 6PPD, commonly found in car tires, to understand its impact on aquatic life. In a 28-day study using zebrafish, researchers discovered that this chemical builds up primarily in the fish's liver and intestines. Once inside, the liver tries to break it down, but the process disrupts the fish's metabolism—specifically affecting how they process fats and proteins. This disruption can damage cell membranes, suggesting that tire pollution poses a significant toxic threat to the health of fish populations.