Factors influencing premature ovarian insufficiency: a systematic review and meta-analysis.

Summary: Premature ovarian insufficiency (POI) happens when a woman's ovaries stop working normally before she turns 40, which can make it hard to get pregnant. Researchers looked at 38 studies involving over 10,000 women to find out what causes it. They discovered that high stress, poor sleep, smoking, hair dye, and chemical exposure can greatly increase the risk. A woman's medical history—like having mumps, pelvic surgery, or a family history of POI—also plays a big part. But there is good news! Eating plenty of vegetables and exercising regularly can help protect your ovaries. By managing stress and making healthy lifestyle choices, women can actively lower their risk.