Fibrin-Targeting Metal-Organic Framework Nanoagent for NIR-Triggered Photothermal Thrombus Ablation.

Summary: Blood clots are a major cause of heart attacks and strokes, but current medicines often don't work well and can cause bad side effects. To fix this, scientists have created a tiny new tool to fight them. They built a microscopic "nanobot" that acts like a heat-seeking missile. It uses a special protein to stick directly to the blood clot. Once it attaches, doctors shine a safe, invisible light (near-infrared) on it. The nanobot absorbs the light, heats up, and melts the clot away. In lab tests, this method safely destroyed over half of the clot's size without harming healthy cells.