From Metabolic Syndrome to Cardiovascular-Kidney-Metabolic Syndrome and Systemic Metabolic Disorder: A Call to Recognize the Progressive Multisystemic Dysfunction.

Summary: For a long time, doctors treated obesity, diabetes, heart disease, and kidney disease as completely separate problems. But today, experts realize these conditions are all connected by the same root cause: unhealthy body fat. Two new medical models—called CKM and SMD—show how fat builds up in the wrong places and damages multiple organs over time. The good news? New weight-loss and diabetes medicines, like GLP-1s and SGLT2 inhibitors, can protect the heart, kidneys, and liver all at once. To help patients better, doctors from different specialties need to team up and treat the whole body together, rather than just focusing on one organ at a time.