Human missense variants in F3 impair the initiation of blood coagulation.

Summary: Your body uses a special protein called Tissue Factor to start a blood clot when you get a cut. The instructions for making this protein are in a gene called F3. Sometimes, people are born with tiny changes (called mutations) in this gene. Scientists wanted to know if these changes affect how well blood clots. They found that common changes do not cause problems. However, some rare changes make it hard for the blood to clot properly. One specific rare change slows down the clotting process by blocking other important proteins. This means some people might have blood that takes longer to clot because of these rare gene changes.