Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2-Mediated Cytoskeletal-Nuclear Mechanotransduction.

Summary: People with diabetes often have a hard time healing from bone injuries. Scientists have finally discovered why: diabetes makes the jelly-like inside of the bone (the bone marrow) too thick and sticky. Stem cells living inside the bone feel this thickness using a special sensor on their surface called TRPV2. The thick marrow squishes the stem cells and actually changes the shape of their DNA, which stops them from turning into new bone. The good news? Scientists found that blocking this TRPV2 sensor stops the squishing effect and helps the stem cells build new bone again, offering a great new way to help diabetic patients heal!