Immunopeptidomics can inform the design of mRNA vaccines for the delivery of

Summary: Tuberculosis (TB) is a deadly lung disease, and right now, we don't have a vaccine that works perfectly to stop it. To make a better vaccine, scientists need to know exactly what parts of the TB bug to attack. A new method called "immunopeptidomics" helps find the exact pieces of the bug that our immune system can see. By putting these tiny pieces into an mRNA vaccine—like the ones used for COVID-19—we can teach the body to fight off TB much better. This is a very promising step toward finally stopping TB!