Inhibition of class IIa HDACs reduces neuroinflammation via NEU1-LAMP1 regulation and promotes M2 macrophage polarization in ischemic stroke.

Summary: When a stroke happens, the brain gets inflamed and damaged. Special immune cells called macrophages can either make this swelling worse or help heal it. Scientists tested a new drug called TMP269 on rats that had strokes. This drug blocks certain proteins (called HDACs) that control inflammation. The results were exciting! The drug helped the immune cells switch to a healing mode instead of a harmful one. It also protected the brain cells and made the stroke damage much smaller. This could lead to better treatments for stroke patients in the future.