Lactate-binding protein DNMT3A in HRMECs promotes angiogenesis by upregulating VEGFA through HIF-1α lactylation.

Summary: Have you ever wondered what causes abnormal blood vessels to grow in the eye and lead to blindness? When the eye doesn't get enough oxygen, a chemical called lactate builds up. Scientists recently discovered that a special helper protein, called DNMT3A, grabs this lactate and takes it deep into the center of the eye's cells. This starts a chain reaction that forces the eye to grow new, leaky blood vessels. By blocking this helper protein or stopping the lactate, doctors might have found a brand-new way to stop blindness and save people's sight!