Local structural flexibility drives oligomorphism in computationally designed protein assemblies.

Summary: Imagine building with LEGOs, but instead of rigid bricks, some pieces have flexible hinges. In nature, proteins often act like these flexible building blocks—they can bend and twist to form different shapes for different jobs, like a coat that expands to fit various packages. Until now, scientists designing artificial proteins mostly tried to build rigid, static structures. However, this study reveals that by intentionally designing "wobbly" parts into proteins, they can create assemblies that snap into multiple, specific shapes rather than just one. Using advanced imaging, researchers found that this controlled flexibility allows for a new generation of versatile, shape-shifting protein tools, opening the door to more complex biological machines.