Lutein ameliorates Parkinson's disease by regulating miR-135b-5p/SIRT1 to inhibit microglial M1 polarization and inflammation.

Summary: Parkinson's disease causes brain damage because immune cells in the brain, called microglia, get too angry and cause swelling (inflammation). Scientists tested a natural nutrient called lutein on mice and brain cells. They found that lutein acts like a calming switch. It blocks a tiny brain signal to boost a helpful protein called SIRT1. This calms the angry brain cells down and turns them into healing cells instead. Mice given lutein moved better and had healthier brains. This means lutein could be a great new way to help fight Parkinson's disease!