Meshed skin grafts placed upside down can take if desiccation is prevented.

Summary: Imagine putting a puzzle piece in upside down and having it still complete the picture perfectly. In surgery, placing a skin graft upside down usually leads to failure. However, researchers discovered a surprising exception using pigs. They found that if "meshed" skin grafts (grafts with small holes to let them stretch) were placed upside down but kept in a strictly wet environment, they survived and healed just as well as grafts placed correctly. Conversely, in a dry environment, these upside-down grafts failed completely. This study proves that keeping a wound moist is a superpower that can overcome even surgical orientation errors.