Microfluidic loading of verteporfin into extracellular vesicles for neuroblastoma therapy.

Summary: Tiny Bubbles, Big Impact: Scientists have developed a "lab-on-a-chip" to turn microscopic bubbles, known as extracellular vesicles (EVs), into super-efficient drug delivery vehicles. By gently mixing these bubbles with Verteporfin, a drug used for neuroblastoma, they created a potent cancer-fighting package. This microfluidic method loads the drug far better than traditional ways while preserving the bubbles' integrity. In tests, these "super-charged" bubbles killed neuroblastoma cells more effectively than the drug alone, offering new hope for precision cancer therapy.