Outcomes of sequential therapy for advanced upper tract urothelial cancer and bladder cancer.

Summary: Imagine two types of cancer in the urinary system: one in the bladder and one higher up in the tubes (called the upper tract). Doctors looked at over 500 patients to see how well standard treatments worked for both. They found that the cancer higher up is much harder to treat. Patients with this upper tract cancer did not respond as well to their first treatments and had a harder time moving on to later treatments because they got too sick or the cancer grew. The study shows we urgently need better, stronger treatments right from the start for patients with upper tract cancer.