Prediction of Prostate Cancer Biochemical Recurrence After Radical Prostatectomy by Collagen Models Using Multiomic Profiles.

Summary: Prostate cancer can sometimes come back even after surgery to remove the prostate. Doctors want to know who is at the highest risk so they can help them sooner and more effectively. In this study, scientists looked at collagen—a protein that gives structure to our tissues and organs. By checking the collagen levels in tumor tissue and urine from over 1,400 men, they found specific patterns. These collagen patterns acted as a warning sign, accurately predicting whose cancer was likely to return. This means a simple urine test or tissue check for collagen might one day help doctors choose the best follow-up care for prostate cancer patients.