Recent advances in single-cell bioinformatics for inferring higher-order chromatin contact maps.

Summary: Imagine your DNA is like a super-long string of instructions that has to be packed tightly into a tiny ball to fit inside a cell. The way it folds creates loops that turn certain genes on or off. Now, scientists have amazing new computer tools that let them look at how this DNA string is folded in just one cell at a time. This helps them understand why cells in our bodies act differently from one another, how we grow, and what goes wrong in diseases. This article reviews the newest computer methods used to map out these tiny, 3D DNA structures.