Target the Heart: a new axis of Alzheimer's disease prevention.

Summary: Imagine if the key to preventing Alzheimer's disease was already in your medicine cabinet! Scientists used a special computer program to watch how tiny fish (zebrafish) behave when given a drug called Cyclosporine A, which shows promise for stopping Alzheimer's. Then, they tested a massive library of approved drugs to see which ones made the fish act the exact same way.

They found 65 drugs that matched, and surprisingly, 14 of them were common heart medicines! Even better, when they mixed a very small amount of the heart medicine with a small amount of Cyclosporine A, the combination worked even better than a large amount of either drug alone. This means teaming up heart drugs with other treatments could be a powerful, safe new way to protect the brain and fight Alzheimer's disease.