The Impact of Estrogen Deficiency on Liver Metabolism: Implications for Hormone Replacement Therapy.

Summary: Fatty liver disease is a huge problem worldwide, affecting one in three people. In women, this disease gets much worse after menopause. Why? Because the body stops making as much estrogen. Without estrogen, fat builds up in the liver, and the body struggles to use sugar properly. Right now, there are no liver treatments made just for women. Many women take hormone replacement therapy (HRT) for menopause, but we don't know enough about how it helps the liver. This review looks at how losing estrogen hurts the liver and how hormone treatments might help protect women as they age.