Unlicensed use of metformin in children and adolescents in the UK.

Summary: Doctors in the UK are prescribing the diabetes drug Metformin to teenagers more frequently, but often not for diabetes. A study analyzing medical records from 2000 to 2010 revealed a significant jump in prescriptions, particularly among girls aged 16-18. The primary reason for this increase was Polycystic Ovary Syndrome (PCOS), followed by diabetes and obesity. Surprisingly, Metformin is not officially approved ("licensed") for treating PCOS or obesity in children. Because its use is rising rapidly for these unapproved conditions, researchers warn that more studies are urgently needed to ensure it is safe and effective for young people.