‘Vital therapy option’: Denosumab does not raise atypical femur fracture risk

Summary: Osteoporosis makes bones weak and fragile. Doctors often prescribe medicines called bisphosphonates to help build them back up. However, taking them for a long time can sometimes cause a rare but serious type of thigh bone break. To prevent this, patients sometimes take a "drug holiday" and pause their medicine.

Another strong medicine, denosumab (Prolia), cannot be stopped suddenly without losing bone quickly. Because of this, doctors worried denosumab might also cause those rare thigh breaks. A massive study of over 270,000 adults (mostly women) looked at the data over four years and found great news! People taking denosumab had no higher risk of these rare thigh bone breaks than those taking standard bisphosphonates. This means denosumab is a safe and vital choice for treating weak bones without the extra worry.

For more details, see rssapp-healio-com-endocrinology at healio.com/news/endocrinology/20260423/vital-therapy-option-denosumab-does-not-raise-atypical-femur-fracture-risk (opens in new tab)